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DLP technology's pivotal role in O2view's versatile medical projection device

dlpQuest Innovations designs and builds the cameras used in the O2view Artemis system. In this article Quest Innovation's DLP projector for the Artemis platform is highlighted. A projection system based on a DLP (Digital Light Processor) is used for the illumination of tissue for near infra-red fluorescence imaging of tumors and spatial oxygen-saturation measurement. The combined technology for molecular imaging (Artemis Camera) and image-guided projection of light (Artemis DMD-Projection System) is of significant benefit for various clinical applications.

In case of tissue oxygen measurements, the application of illumination patterns of specific near-infrared light and concomitant read out of reflected light from non-illuminated areas theoretically will reveal information from deeper structures. As regards tumor surgery, photodynamic therapy for elimination of tumor tissue is the most exciting and even more demanding, in that the areas to be illuminated perfectly have to match the areas where cancerous tissue is detected. Several performance criteria had to be met for the projection system: mixing wavelengths from different light sources via a 3-channel prism; apochromatic from 430 to 1,000 nm; the projector's zoom-function to follow the Artemis camera zoom settings; the angle of projection to adapt to the full working distance range; and the integration of O2view's custom camera controls with the DLP-chip.


mouseIn 2007 and 2008, Artemis was developed as a medical device to quantitatively and qualitatively reveal spatial tissue oxygen-saturation information, important for surgical procedures in general and cardio, reconstructive and trauma surgery in particular. Many enquiries with potential users revealed an absence of interest in this tissue oxygen visualization technology. An application breakthrough came in late 2008 when surgical oncologists displayed their interest in our technology. Using non-invasive imaging technologies like CT, MRI and PET, cancer can be detected much earlier and the tumor can subsequently be removed using minimally invasive techniques or by open surgery. It is of great importance that during surgery the tumor is completely removed with sufficient tumor-free margin. Whilst operating, however, it is extremely difficult to discriminate between tumor and normal tissue. Identification of lymph node metastases is also hard while operating. If, under imaging, intra-operative identification of tumor-free margins and local (lymph node) metastases is possible, and their subsequent radical removal, the life expectancy of cancer patients will be greatly improved.

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